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KMID : 0369819970270030165
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Jorunal of Korean Pharmaceutical Sciences
1997 Volume.27 No. 3 p.165 ~ p.171
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Inclusion Complex of Analgesic and antiinfiammatory Agents with Cyclodextrins (Ⅱ) : Effect of 2-Hydroxypropyl-β-cyclodextrin on the Release of Ibuprofen Suppository
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오인준/Oh IJ
이미영/이용복/신상철/Lee MY/Lee YB/Shin SC
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Abstract
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Ibuprofen, a nonsteroidal antiinflammatory, analgesic and antipyretic drug, has several limitations in clinical application because of low solubility in water and gastrointestinal irritation. Effect of ibuprofen/2?Hydroxypropyl?β?cyclodextrin(HPβCD) inclusion compound on release of suppository was investigated. Complex formation was confirmed by 1H?and13C?NMR spectroscopy. The release of ibuprofen from suppository base in vitro was significantly increased by the complexation with HPβCD. The release of ibuprofen from hydrophilic base was faster than that from hydrophobic base. In vivo studies, the release rate of ibuprofen from suppository was accelerated after rectal administration in complex form. This results suggested that ibuprofen/HPβCD complex can be practically used for suppository to have faster effect of ibuprofen with reduced side effect.
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KEYWORD
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Ibuprofen, Hydroxypropyl-β-cyclodextrin, Inclusion compound, Complexation, Suppository, Rectal absorption
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